Camptothecin and its analogues: a review on their chemotherapeutic potential

被引：131

作者：

Sriram, D ^{[1
]}

Yogeeswari, P ^{[1
]}

Thirumurugan, R ^{[1
]}

Bal, TR ^{[1
]}

机构：

[1] Birla Inst Technol & Sci, Pharm Grp, Med Chem Res Lab, Pilani 333031, Rajasthan, India

来源：

NATURAL PRODUCT RESEARCH | 2005年 / 19卷 / 04期

关键词：

camptothecin; anticancer; topoisomerase I inhibitors;

D O I：

10.1080/14786410412331299005

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Topoisomerase I (Topo-I) is a major target for anticancer drug discovery and design. As a result, Topo-I inhibitors constitute an important class of the current anticancer drugs. To date, all of the Topo-I inhibitors that have been clinically evaluated are analogues of camptothecin (CPT), an extract of the Chinese tree Camptotheca acuminata. CPT has shown significant antitumor activity to lung, ovarian, breast, pancreas and stomach cancers. In this article the, phytochemical aspect, and various structural modifications are comprehensively reviewed as in rings A, B, C, D and E. Biological activity of camptothecin, other than anticancer, reported till the year 2003 has also been discussed.

引用

页码：393 / 412

页数：20

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