Telomere shortening in atherosclerosis

被引：490

作者：

Samani, NJ

Boultby, R

Butler, R

Thompson, JR

Goodall, AH

机构：

[1] Univ Leicester, Glenfield Hosp, Dept Cardiol, Leicester LE3 9QP, Leics, England

[2] Univ Leicester, Glenfield Hosp, Dept Ophthalmol, Leicester LE3 9QP, Leics, England

[3] Univ Leicester, Glenfield Hosp, Dept Pathol, Leicester LE3 9QP, Leics, England

来源：

LANCET | 2001年 / 358卷 / 9280期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0140-6736(01)05633-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Eukaryotic chromosomes end with telomeres, which shorten with cellular ageing. We investigated whether atherosclerosis is associated with systemic evidence of accelerated cellular ageing. We compared mean length of terminal restriction fragments (TRF), a measure of average telomere size, in leucocyte DNA of ten patients with severe coronary artery disease (CAD) with that of 20 controls without CAD. Adjusting for age and sex, cases had mean TRF lengths of 303 (SD 90) base pairs shorter than those of controls (p=0.002)-ie, equivalent in size to individuals with no CAD who are 8.6 years older. Although this is a pilot study, the findings could be relevant to the pathogenesis of atherosclerosis.

引用

页码：472 / 473

页数：2

共 5 条

[1]

ERIKSSON JG, 1999, BRIT MED J, V318, P7

[2] Mechanisms of disease - Atherosclerosis - An inflammatory disease [J].