Compounds for the prevention and treatment of noise-induced hearing loss

被引：116

作者：

Lynch, ED

Kil, J

机构：

[1] Seattle, WA 98103

来源：

DRUG DISCOVERY TODAY | 2005年 / 10卷 / 19期

关键词：

D O I：

10.1016/S1359-6446(05)03561-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Noise-induced hearing loss (NIHL) is the leading occupational disease and a major contributor to the development of age-related hearing loss. The pharmacological prevention and treatment of NIHL has been under preclinical investigation for the past 20 years. Promising treatments have now been identified and entered into clinical development. Within the next five years, safe and effective drugs could be approved as the first generation of otoprotectants. This review covers strategies that are under investigation for NIHL. Drugs that effectively prevent and treat NIHL will have a significant impact on medical costs, disability compensation and several issues affecting the quality of life.

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收藏

页码：1291 / 1298

页数：8

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