Porous NiTi for bone implants: A review

被引：454

作者：

Bansiddhi, A. ^{[1
]}

Sargeant, T. D. ^{[1
]}

Stupp, S. I. ^{[1
]}

Dunand, D. C. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

来源：

ACTA BIOMATERIALIA | 2008年 / 4卷 / 04期

关键词：

nitinol; cellular metals; biocompatibility; chemical modification; bioactive surfaces;

D O I：

10.1016/j.actbio.2008.02.009

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

NiTi foams are unique among biocompatible porous metals because of their high recovery strain (due to the shape-memory or superelastic effects) and their low stiffness facilitating integration with bone structures. To optimize NiTi foams for bone implant applications, two key areas are under active study: synthesis of foams with optimal architectures, microstructure and mechanical properties; and tailoring of biological interactions through modifications of pore surfaces. This article reviews recent research on NiTi foams for bone replacement, focusing on three specific topics: (i) surface modifications designed to create bio-inert porous NiTi surfaces with low Ni release and corrosion, as well as bioactive surfaces to enhance and accelerate biological activity; (ii) in vitro and in vivo biocompatibility studies to confirm the long-term safety of porous NiTi implants; and (iii) biological evaluations for specific applications, such as in intervertebral fusion devices and bone tissue scaffolds. Possible future directions for bio-performance and processing studies are discussed that could lead to optimized porous NiTi implants. (c) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：773 / 782

页数：10

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