Neurons may live for decades with neurofibrillary tangles

被引:328
作者
Morsch, R
Simon, W
Coleman, PD
机构
[1] Univ Rochester, Med Ctr, Alzheimer Dis Ctr, Rochester, NY 14642 USA
[2] Univ Rochester, Med Ctr, Dept Neurobiol & Anat, Rochester, NY 14642 USA
[3] Univ Rochester, Med Ctr, Dept Biochem & Biophys, Rochester, NY 14642 USA
关键词
Alzheimer disease; neuron death; neurofibrillary tangles;
D O I
10.1097/00005072-199902000-00008
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neurons containing neurofibrillary tangles (NFT) are one of the pathological hallmarks of Alzheimer disease (AD). It is known that this population of neurons express gene products and thus function to some degree, but it is unknown how long these neurons may survive with NFT. It is also thought that the formation of NFT results in the death of neurons. Using quantitative data on neuron loss and NFT formation as a function of disease duration, we have generated a computer program that models both the degeneration of CA1 hippocampal neurons and the formation of NFT in these neurons in AD. Modeling various neuron survival times with NFT and altering selected assumptions upon which the models are based, we arrive at the conclusions that 1) CA1 hippocampal neurons survive with NFT for about 20 years, and 2) NFT may not be obligatory for death of CA1 hippocampal neurons in AD.
引用
收藏
页码:188 / 197
页数:10
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