Anti-HLA antibodies in heart transplantation

被引：46

作者：

Vasilescu, ER

Ho, EK

de la Torre, L

Itescu, S

Marboe, C

Cortesini, R

Suciu-Foca, N

Mancini, D

机构：

[1] Columbia Univ, Dept Pathol, New York, NY 10032 USA

[2] Columbia Univ, Dept Internal Med, New York, NY 10032 USA

来源：

TRANSPLANT IMMUNOLOGY | 2004年 / 12卷 / 02期

关键词：

HLA antibodies; heart transplantation; transplant-related coronary artery disease;

D O I：

10.1016/j.trim.2003.08.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have analyzed the relationship between the development of transplant-related coronary artery disease (TRCAD) and the following potential risk factors: (a) number of HLA mismatches between recipient and donor; (b) production of anti-HLA antibodies; (c) growth of lymphocytes infiltrating the graft; and (d) frequency of biopsy proven episodes of acute rejection. The study population consisted of 285 adult heart allograft recipients who were monitored over a period of two years or more. The results demonstrate a significant correlation between TRCAD, generation of anti-HLA class II antibodies and potential of lymphocytes infiltrating the graft to proliferate ex-vivo in medium containing IL-2. Humoral and cellular immune responses to HLA-DR antigens expressed by the graft seem to underlie the development of TRCAD. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：177 / 183

页数：7

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