Common polymorphisms in the coding part of the IL4-receptor gene

被引：99

作者：

Deichmann, K

Bardutzky, J

Forster, J

Heinzmann, A

Kuehr, J

机构：

[1] University Children's Hospital, University of Freiburg, D 79106 Freiburg

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 231卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.6115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present 12 common polymorphisms in the coding part of the IL4 receptor gene, 5 of them leading to amino acid changes of the gene product. The IL4-receptor represents a membrane bound protein on T-cells binding the cytokine IL4 and mediating its effect. The polymorphisms and mutations described here might be useful to shed light on the structure and functioning of the IL4 receptor. Furthermore, the protein represents a candidate gene for several immunological disorders involving the IL4 pathway. (C) 1997 Academic Press.

引用

页码：696 / 697

页数：2

共 11 条

[1] THE HEMATOPOIETIN RECEPTOR SUPERFAMILY
COSMAN, D
[J]. CYTOKINE, 1993, 5 (02) : 95 - 106
[2] DETECTION OF POINT MUTATIONS IN THE ANDROGEN RECEPTOR GENE USING NONISOTOPIC SINGLE-STRAND CONFORMATION POLYMORPHISM ANALYSIS
HIORT, O
WODTKE, A
STRUVE, D
ZOLLNER, A
SINNECKER, GHG
ALBERS, N
BEYE, M
BEYER, P
BIRR, C
BLUNCK, W
BRACK, C
BRAMSWIG, J
DORR, HG
GAL, A
HECKER, W
HEIDEMANN, P
HEINRICH, U
HEISE, HR
HESSE, V
HINKEL, M
HOEPFFNER, W
HOLDER, M
KEIM, L
KLASEN, M
KORSCH, E
KRUGER, G
LANDENDORFER, W
MIX, M
MORLOT, M
MUHLENBERG, R
OTTEN, A
PARTSCH, CJ
PELZ, L
VONPETRYKOWSKI, W
RABL, W
REICH, H
SCHENK, B
SCHNABEL, D
SIPPELL, W
[J]. HUMAN MOLECULAR GENETICS, 1994, 3 (07) : 1163 - 1166
[3] HUMAN INTERLEUKIN-4 RECEPTOR CONFERS BIOLOGICAL RESPONSIVENESS AND DEFINES A NOVEL RECEPTOR SUPERFAMILY
IDZERDA, RL
MARCH, CJ
MOSLEY, B
LYMAN, SD
VANDENBOS, T
GIMPEL, SD
DIN, WS
GRABSTEIN, KH
WIDMER, MB
PARK, LS
COSMAN, D
BECKMANN, MP
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (03) : 861 - 873
[4] RECEPTORS FOR B-CELL STIMULATORY FACTOR-I EXPRESSED ON CELLS OF HEMATOPOIETIC LINEAGE
OHARA, J
PAUL, WE
[J]. NATURE, 1987, 325 (6104) : 537 - 540
[5] ORITA M, 1989, GENOMICS, V5, P156
[6] CHARACTERIZATION OF THE HIGH-AFFINITY CELL-SURFACE RECEPTOR FOR MURINE B-CELL-STIMULATING FACTOR-I
PARK, LS
FRIEND, D
GRABSTEIN, K
URDAL, DL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (06) : 1669 - 1673
[7] THE INTERLEUKIN-4 RECEPTOR GENE (IL4R) MAPS TO 16P11.2-16P12.1 IN HUMAN AND TO THE DISTAL REGION OF MOUSE CHROMOSOME-7
PRITCHARD, MA
BAKER, E
WHITMORE, SA
SUTHERLAND, GR
IDZERDA, RL
PARK, LS
COSMAN, D
JENKINS, NA
GILBERT, DJ
COPELAND, NG
BECKMANN, MP
[J]. GENOMICS, 1991, 10 (03) : 801 - 806
[8] INTERACTION OF IL-2R-BETA AND GAMMA(C) CHAINS WITH JAK1 AND JAK3 - IMPLICATIONS FOR XSCID AND XCID
RUSSELL, SM
JOHNSTON, JA
NOGUCHI, M
KAWAMURA, M
BACON, CM
FRIEDMANN, M
BERG, M
MCVICAR, DW
WITTHUHN, BA
SILVENNOINEN, O
GOLDMAN, AS
SCHMALSTIEG, FC
IHLE, JN
OSHEA, JJ
LEONARD, WJ
[J]. SCIENCE, 1994, 266 (5187) : 1042 - 1045
[9] RUSSELL SM, 1993, SCIENCE, V262, P1180
[10] DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS
SANGER, F
NICKLEN, S
COULSON, AR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) : 5463 - 5467

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