Uberon, an integrative multi-species anatomy ontology

被引：447

作者：

Mungall, Christopher J. ^{[1
]}

Torniai, Carlo ^{[2
]}

Gkoutos, Georgios V. ^{[3
]}

Lewis, Suzanna E. ^{[1
]}

Haendel, Melissa A. ^{[2
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Genom Div, Berkeley, CA 94720 USA

[2] Oregon Hlth & Sci Univ, Lib & Dept Med Informat & Clin Epidemiol, Portland, OR 97239 USA

[3] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

来源：

GENOME BIOLOGY | 2012年 / 13卷 / 01期

基金：

美国国家卫生研究院;

关键词：

PHENOTYPE ONTOLOGY; INFORMATION; TOOL; INTEROPERABILITY; EVOLUTION; FRAMEWORK; HOMOLOGY; DATABASE; SUPPORT; SYSTEM;

D O I：

10.1186/gb-2012-13-1-r5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We present Uberon, an integrated cross-species ontology consisting of over 6,500 classes representing a variety of anatomical entities, organized according to traditional anatomical classification criteria. The ontology represents structures in a species-neutral way and includes extensive associations to existing species-centric anatomical ontologies, allowing integration of model organism and human data. Uberon provides a necessary bridge between anatomical structures in different taxa for cross-species inference. It uses novel methods for representing taxonomic variation, and has proved to be essential for translational phenotype analyses. Uberon is available at http://uberon.org

引用

页数：20

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