[1:3] Site-differentiated and sulfide-bridged cubane clusters in chemistry and biology

被引：17

作者：

Holm, RH ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

PURE AND APPLIED CHEMISTRY | 1998年 / 70卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1351/pac199870040931

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A subset of protein-bound Fe4S4 cubane-type clusters occurs in a [1:3] iron site-differentiated form in which the terminal ligand at the unique site is not a cysteinyl group. Reactions of synthetic site-differentiated [Fe4S4](2+) clusters are summarized, including removal of the unique iron atom to afford the [Fe3S4](0) cuboidal cluster, thereby completing the synthesis of analogues of native iron-sulfur clusters with nuclearity 14. The cuboidal cluster supports metal ion insertion reactions leading to a set of heterometal cubane type clusters MFe3S4, whose redox potentials have been determined as a function of M. Sulfide-bridged double cubanes [MFe3S4]-S-[MFe3S4] (M = Mo, Fe; M-2 = MoFe), another type of site-differentiated cluster, have been prepared as precursors in potential cluster rearrangement reactions leading to the core [MFe6S9] with the same topology as the FeMo-cofactor of nitrogenase.

引用

页码：931 / 938

页数：8

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