Genomic map of Clostridium perfringens strain 13

被引:20
作者
Shimizu, T [1 ]
Ohshima, S [1 ]
Ohtani, K [1 ]
Shimizu, T [1 ]
Hayashi, H [1 ]
机构
[1] Univ Tsukuba, Inst Basic Med Sci, Dept Microbiol, Tsukuba, Ibaraki 3058575, Japan
关键词
Clostridium perfringens; genome map; genome organization; pulsed field gel electrophoresis; virulence plasmid;
D O I
10.1111/j.1348-0421.2001.tb01278.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A physical and genetic map of Clostridium perfringens strain 13 was constructed. C, perfringens strain 13 was found to have a 3.1-Mb chromosome and a large 50-kb plasmid, indicating that strain 13 has a relatively small genome among C, perfringens strains. A total of 313 genetic markers were mapped on the chromosome of strain 13, Compared with the physical and genetic map of C, perfringens CPN50, strain 13 had a quite similar genome organization, but with a large deletion (similar to 400 kb) in a particular segment of the chromosome. Among several toxin genes, a beta2 toxin gene that is a novel virulence gene in C. perfringens was found to be located on the 50-kb plasmid.
引用
收藏
页码:179 / 189
页数:11
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