Occurrence of epidermal nerve endings in glabrous and hairy skin of the rat foot after sciatic nerve regeneration

被引:32
作者
Stankovic, N
Johansson, O
Hildebrand, C
机构
[1] LINKOPING UNIV,FAC HLTH SCI,DEPT CELL BIOL,NEUROBIOL UNIT,S-58185 LINKOPING,SWEDEN
[2] LINKOPING UNIV,FAC HLTH SCI,DEPT PLAST SURG HAND SURG & BURNS,S-58185 LINKOPING,SWEDEN
[3] KAROLINSKA INST,EXPTL DERMATOL UNIT,DEPT NEUROSCI,STOCKHOLM,SWEDEN
关键词
glabrous skin; hairy skin; intraepidermal nerve endings; nerve crush; neurotomy; regeneration; PGP; 9.5; rat (Sprague Dawley);
D O I
10.1007/s004410050576
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The occurrence and distribution of intraepidermal nerve endings in hairy and glabrous skin of the rat foot was examined in normal cases and three months after sciatic neurotomy/suture or a crush lesion. The nerve endings were visualized in cryostate sections with antibodies against protein gene product 9.5. Normal glabrous skin exhibited 23.3 endings/mm length. Neurotomy/suture cases had 6.1 endings/mm. In rats with nerve crush injury the occurrence was normal, but the intraepidermal nerve endings tended to be abnormally short and occurred mainly in the basal layer of the epidermis. In sections from hairy skin countings were not possible. Subjective evaluation indicated that the occurrence of dermal and epidermal axon profiles usually was very deficient after neurotomy/suture and essentially normal after crush. Skin samples from the contralateral side of operated animals showed a normal occurrence and distribution of nerve endings. We also noted that cases subjected to neurotomy/suture showed increased numbers of protein gene product 9.5-immunoreactive intraepidermal cells and an abnormally thin epidermis. We suggest that a highly deficient occurrence of intraepidermal nerve endings may be one factor behind the unsatisfactory restitution of the sensory function of the hand typically seen in patients subjected to neurotomy and suture.
引用
收藏
页码:161 / 166
页数:6
相关论文
共 35 条
[1]   3 DIMENSIONAL ANALYSIS OF UNMYELINATED FIBERS IN NORMAL AND PATHOLOGIC AUTONOMIC NERVES [J].
AGUAYO, AJ ;
BRAY, GM ;
TERRY, LC ;
SWEEZEY, E .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1976, 35 (02) :136-151
[2]   THE INNERVATION OF HUMAN EPIDERMIS [J].
ARTHUR, RP ;
SHELLEY, WB .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1959, 32 (03) :397-411
[3]  
CAUNA N, 1973, J ANAT, V2, P277
[4]  
COONS A H, 1958, Gen Cytochem Methods, V1, P399
[5]   RE-INNERVATION OF GLABROUS SKIN IN BABOONS - PROPERTIES OF CUTANEOUS MECHANORECEPTORS SUBSEQUENT TO NERVE CRUSH [J].
DYKES, RW ;
TERZIS, JK .
JOURNAL OF NEUROPHYSIOLOGY, 1979, 42 (05) :1461-1478
[6]  
Gelberman R H, 1978, J Hand Surg Am, V3, P313
[7]  
Greene EC., 1963, ANATOMY RAT
[9]  
Hebel R., 1986, ANATOMY EMBRYOLOGY L
[10]   SCHWANN-CELL BASAL LAMINA AND NERVE REGENERATION [J].
IDE, C ;
TOHYAMA, K ;
YOKOTA, R ;
NITATORI, T ;
ONODERA, S .
BRAIN RESEARCH, 1983, 288 (1-2) :61-75