Dynamic diastereomeric salt resolution of narwedine and its transformation to (-)-galanthamine

被引：28

作者：

Chaplin, DA

Johnson, NB

Paul, JM

Potter, GA

机构：

[1] Chirotech Technol Ltd, Cambridge CB4 4WE, England

[2] Chirosci R&D Ltd, Cambridge CB4 4WE, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(98)01424-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Racemic narwedine may be resolved by means of a dynamic diastereomeric salt formation using di-p-toluoyl-o-tartaric acid. Both the 1:1 and 2:1 salts are formed in excellent yields and diastereomeric excesses. These salts are reduced in a highly diastereoselective and chemoselective manner to give (-)-galanthamine. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6777 / 6780

页数：4

共 11 条

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