Unravelling the effects of the environment and host genotype on the gut microbiome

被引：1074

作者：

Spor, Ayme ^{[1
]}

Koren, Omry ^{[1
]}

Ley, Ruth ^{[1
]}

机构：

[1] Cornell Univ, Dept Microbiol, Ithaca, NY 14853 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

SEGMENTED FILAMENTOUS BACTERIA; ADVANCED INTERCROSS LINE; GENOME-WIDE ASSOCIATION; SYMBIOTIC BACTERIA; INTESTINAL MICROBIOTA; METABOLIC SYNDROME; FECAL MICROFLORA; EPITHELIAL-CELLS; CROHNS-DISEASE; BODY HABITATS;

D O I：

10.1038/nrmicro2540

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To what extent do host genetics control the composition of the gut microbiome? Studies comparing the gut microbiota in human twins and across inbred mouse lines have yielded inconsistent answers to this question. However, candidate gene approaches, in which one gene is deleted or added to a model host organism, show that a single host gene can have a tremendous effect on the diversity and population structure of the gut microbiota. Now, quantitative genetics is emerging as a highly promising approach that can be used to better understand the overall architecture of host genetic influence on the microbiota, and to discover additional host genes controlling microbial diversity in the gut. In this Review, we describe how host genetics and the environment shape the microbiota, and how these three factors may interact in the context of chronic disease.

引用

页码：279 / 290

页数：12

共 121 条

[1] The gut microbiota of toll-like receptor 2-deficient mice exhibits lineage-specific modifications [J].

Albert, Eric J. ;

Sommerfeld, Katrin ;

Gophna, Sharon ;

Marshall, Jean S. ;

Gophna, Uri .

ENVIRONMENTAL MICROBIOLOGY REPORTS, 2009, 1 (01) :65-70

[2] Quantitative PCR assays for mouse enteric flora reveal strain-dependent differences in composition that are influenced by the microenvironment [J].

Alexander, A. Deloris ;

Orcutt, Roger P. ;

Henry, JaNell C. ;

Baker, Joseph ;

Bissahoyo, Anika C. ;

Threadgill, David W. .

MAMMALIAN GENOME, 2006, 17 (11) :1093-1104

[3] RELMβ/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract [J].

Artis, D ;

Mei, LW ;

Keilbaugh, SA ;

He, WM ;

Brenes, M ;

Swain, GP ;

Knight, PA ;

Donaldson, DD ;

Lazar, MA ;

Miller, HRP ;

Schad, GA ;

Scott, P ;

Wu, GD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (37) :13596-13600

[4] Pathogenic and Protective Roles of MyD88 in Leukocytes and Epithelial Cells in Mouse Models of Inflammatory Bowel Disease [J].

Asquith, Mark J. ;

Boulard, Olivier ;

Powrie, Fiona ;

Maloy, Kevin J. .

GASTROENTEROLOGY, 2010, 139 (02) :519-529

[5]

Baker Phillip I, 2009, Expert Rev Gastroenterol Hepatol, V3, P535, DOI 10.1586/egh.09.47

[6] Host-bacteria interactions in the intestine: homeostasis to chronic inflammation [J].

Barbosa, Theolis ;

Rescigno, Maria .

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 2010, 2 (01) :80-97

[7] Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease [J].

Barrett, Jeffrey C. ;

Hansoul, Sarah ;

Nicolae, Dan L. ;

Cho, Judy H. ;

Duerr, Richard H. ;

Rioux, John D. ;

Brant, Steven R. ;

Silverberg, Mark S. ;

Taylor, Kent D. ;

Barmada, M. Michael ;

Bitton, Alain ;

Dassopoulos, Themistocles ;

Datta, Lisa Wu ;

Green, Todd ;

Griffiths, Anne M. ;

Kistner, Emily O. ;

Murtha, Michael T. ;

Regueiro, Miguel D. ;

Rotter, Jerome I. ;

Schumm, L. Philip ;

Steinhart, A. Hillary ;

Targan, Stephan R. ;

Xavier, Ramnik J. ;

Libioulle, Cecile ;

Sandor, Cynthia ;

Lathrop, Mark ;

Belaiche, Jacques ;

Dewit, Olivier ;

Gut, Ivo ;

Heath, Simon ;

Laukens, Debby ;

Mni, Myriam ;

Rutgeerts, Paul ;

Van Gossum, Andre ;

Zelenika, Diana ;

Franchimont, Denis ;

Hugot, Jean-Pierre ;

de Vos, Martine ;

Vermeire, Severine ;

Louis, Edouard ;

Cardon, Lon R. ;

Anderson, Carl A. ;

Drummond, Hazel ;

Nimmo, Elaine ;

Ahmad, Tariq ;

Prescott, Natalie J. ;

Onnie, Clive M. ;

Fisher, Sheila A. ;

Marchini, Jonathan ;

Ghori, Jilur .

NATURE GENETICS, 2008, 40 (08) :955-962

[8] Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors [J].

Benson, Andrew K. ;

Kelly, Scott A. ;

Legge, Ryan ;

Ma, Fangrui ;

Low, Soo Jen ;

Kim, Jaehyoung ;

Zhang, Min ;

Oh, Phaik Lyn ;

Nehrenberg, Derrick ;

Hua, Kunjie ;

Kachman, Stephen D. ;

Moriyama, Etsuko N. ;

Walter, Jens ;

Peterson, Daniel A. ;

Pomp, Daniel .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (44) :18933-18938

[9] Bacterial diversity in the oral cavity of 10 healthy individuals [J].

Bik, Elisabeth M. ;

Long, Clara Davis ;

Armitage, Gary C. ;

Loomer, Peter ;

Emerson, Joanne ;

Mongodin, Emmanuel F. ;

Nelson, Karen E. ;

Gill, Steven R. ;

Fraser-Liggett, Claire M. ;

Relman, David A. .

ISME JOURNAL, 2010, 4 (08) :962-974

[10] Bacteriotherapy using fecal flora - Toying with human motions [J].

Borody, TJ ;

Warren, EF ;

Leis, SM ;

Surace, R ;

Ashman, O ;

Siarakas, S .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2004, 38 (06) :475-483

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