Direct interferon-γ-mediated protection caused by a recombinant coxsackievirus B3

被引：29

作者：

Henke, A ^{[1
]}

Zell, R ^{[1
]}

Martin, U ^{[1
]}

Stelzner, A ^{[1
]}

机构：

[1] Univ Jena, Ctr Med, Inst Virol & Antiviral Therapy, D-07745 Jena, Germany

来源：

VIROLOGY | 2003年 / 315卷 / 02期

关键词：

recombinant coxsackievirus; myocarditis; interferon-gamma; protection; therapy;

D O I：

10.1016/S0042-6822(03)00538-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Coxsackievirus B3 (CVB3) is one of the most important causes of viral myocarditis. Cytokines are involved in the control of CVB3 replication and pathogenesis. Local expression of specific cytokines by recombinant CVB3 confers prevention of virus-caused myocarditis. Expression of IFN-gamma by CVB3(IFN-gamma) protected BALB/c and C57BL/6 mice when the lethal infection with the highly pathogenic CVB3H3 variant was given directly after or prior to CVB3(IFN-gamma) inoculation by decreasing the viral load and spread as well as tissue destruction. This direct effect was not restricted to the homologous virus. In vitro, cocultivation of CVB3(IFN-gamma)-infected cells induced a reduction of CVB3H3 replication and virus-induced cytopathogenicity. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：335 / 344

页数：10

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