Live and let die in the intestinal epithelium

被引：172

作者：

Sancho, E ^{[1
]}

Batlle, E ^{[1
]}

Clevers, H ^{[1
]}

机构：

[1] Koninklijke Nederlandse Akad Wetenschappen, Hubrecht Lab, Ctr Biomed Genet, Utrecht, Netherlands

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.ceb.2003.10.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The intestinal epithelium is a relatively simple developmental system and a prime example of tissue renewal from a source of multipotent stem cells. Throughout adulthood, intestinal epithelial proliferation, cell-fate specification and differentiation are coupled to migration in discrete units known as crypts of Lieberkuhn. Physically guided by Eph receptors and their ligands, the ephrins, stem cell progeny transit through the proliferation/differentiation switch, and Notch diversifies their subsequent fates. Writ signalling appears to control most of these events.

引用

页码：763 / 770

页数：8

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