Epigenetic aspects of X-chromosome dosage compensation

被引：82

作者：

Park, Y ^{[1
]}

Kuroda, MI ^{[1
]}

机构：

[1] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA

来源：

SCIENCE | 2001年 / 293卷 / 5532期

关键词：

D O I：

10.1126/science.1063073

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The X chromosomes of mammals and fruit flies exhibit unusual properties that have evolved to deal with the different dosages of X-linked genes in mates (XY) and females (XX). The X chromosome dosage-compensation mechanisms discovered in these species are evolutionarily unrelated, but exhibit surprising parallels in their regulatory strategies. These features include the importance of noncoding RNAs, and epigenetic spreading of chromatin-modifying activities.

引用

页码：1083 / 1085

页数：3

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