Rhodium-catalyzed asymmetric 1,6-addition of aryl zinc reagents to dienones

被引：95

作者：

Hayashi, T ^{[1
]}

Yamamoto, S ^{[1
]}

Tokunaga, N ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 27期

关键词：

1,6-addition; asymmetric catalysis; organometallic reagents; rhodium; zinc;

D O I：

10.1002/anie.200500678

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A highly enantioselective methodology allows the preparation of α,β-unsaturated ketones that contain a new stereogenic center at the C5 position. This approach is realized through the title reaction in the presence of chlorotrimethylsilane as a Lewis acid and a rhodium/(S)-binap complex as the catalyst followed by acidic hydrolysis (see scheme). binap = 2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4224 / 4227

页数：4

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