Large competitive kinetic isotope effects in human 15-lipoxygenase catalysis measured by a novel HPLC method

被引：74

作者：

Lewis, ER ^{[1
]}

Johansen, E ^{[1
]}

Holman, TR ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1999年 / 121卷 / 06期

关键词：

D O I：

10.1021/ja983083g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：1395 / 1396

页数：2

共 19 条

[1] DEMONSTRATION BY EPR SPECTROSCOPY OF FUNCTIONAL ROLE OF IRON IN SOYBEAN LIPOXYGENASE-1 [J].

DEGROOT, JJM ;

VELDINK, GA ;

VLIEGENTHART, JFG ;

BOLDINGH, J ;

WEVER, R ;

VANGELDER, BF .

BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 377 (01) :71-79

[2] MECHANISM OF ACTION OF SOYBEAN LIPOXYGENASE-1 - STOPPED-FLOW KINETIC STUDY OF FORMATION AND CONVERSION OF YELLOW AND PURPLE ENZYME SPECIES [J].

EGMOND, MR ;

FASELLA, PM ;

VELDINK, GA ;

VLIEGENTHART, JFG ;

BOLDINGH, J .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1977, 76 (02) :469-479

[3] IDENTIFICATION OF A SPECIFIC METHIONINE IN MAMMALIAN 15-LIPOXYGENASE WHICH IS OXYGENATED BY THE ENZYME PRODUCT 13-HPODE - DISSOCIATION OF SULFOXIDE FORMATION FROM SELF-INACTIVATION [J].

GAN, QF ;

WITKOP, GL ;

SLOANE, DL ;

STRAUB, KM ;

SIGAL, E .

BIOCHEMISTRY, 1995, 34 (21) :7069-7079

[4] Defining the arachidonic acid binding site of human 15-lipoxygenase - Molecular modeling and mutagenesis [J].

Gan, QF ;

Browner, MF ;

Sloane, DL ;

Sigal, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (41) :25412-25418

[5] SOYBEAN LIPOXYGENASE-1 ENZYMICALLY FORMS BOTH (9S)-HYDROPEROXIDES AND (13S)-HYDROPEROXIDES FROM LINOLEIC-ACID BY A PH-DEPENDENT MECHANISM [J].

GARDNER, HW .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 1001 (03) :274-281

[6] UNDERSTANDING C-H BOND OXIDATIONS - H-CENTER-DOT AND H- TRANSFER IN THE OXIDATION OF TOLUENE BY PERMANGANATE [J].

GARDNER, KA ;

MAYER, JM .

SCIENCE, 1995, 269 (5232) :1849-1851

[7] Lipoxygenase reaction mechanism: Demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover [J].

Glickman, MH ;

Klinman, JP .

BIOCHEMISTRY, 1996, 35 (39) :12882-12892

[8] EXTREMELY LARGE ISOTOPE EFFECTS IN THE SOYBEAN LIPOXYGENASE-LINOLEIC ACID REACTION [J].

GLICKMAN, MH ;

WISEMAN, JS ;

KLINMAN, JP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (02) :793-794

[9] NATURE OF RATE-LIMITING STEPS IN THE SOYBEAN LIPOXYGENASE-1 REACTION [J].

GLICKMAN, MH ;

KLINMAN, JP .

BIOCHEMISTRY, 1995, 34 (43) :14077-14092

[10] Spectroscopic and functional characterization of a ligand coordination mutant of soybean lipoxygenase-1: First coordination sphere analogue of human 15-lipoxygenase [J].

Holman, TR ;

Zhou, J ;

Solomon, EI .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (48) :12564-12572

← 1 2 →