The stats of cancer - New molecular targets come of age

被引：1955

作者：

Yu, H ^{[1
]}

Jove, R

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Program Immunol, Tampa, FL 33612 USA

[2] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Mol Oncol Program, Tampa, FL 33612 USA

[3] Univ S Florida, Coll Med, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 02期

关键词：

D O I：

10.1038/nrc1275

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain angiogenesis and evade immune surveillance. STAT proteins - especially STAT3 and STAT5 - regulate all of these processes and are persistently activated in a surprisingly large number of human cancers. Consequently, STAT proteins are emerging - unexpectedly - as ideal targets for cancer therapy.

引用

页码：97 / 105

页数：9

共 128 条

[1] Roles of STAT3 defined by tissue-specific gene targeting
Akira, S
[J]. ONCOGENE, 2000, 19 (21) : 2607 - 2611
[2] Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma
Aoki, Y
Feldman, GM
Tosato, G
[J]. BLOOD, 2003, 101 (04) : 1535 - 1542
[3] VEGF differentially activates STAT3 in microvascular endothelial cells
Bartoli, M
Platt, DH
Lemtalsi, T
Gu, XL
Brooks, SE
Marrero, MB
Caldwell, RB
[J]. FASEB JOURNAL, 2003, 17 (09) : 1562 - +
[4] Battle T. E., 2002, Current Molecular Medicine (Hilversum), V2, P381, DOI 10.2174/1566524023362456
[5] Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts
Berg, T
Cohen, SB
Desharnais, J
Sonderegger, C
Maslyar, DJ
Goldberg, J
Boger, DL
Vogt, PK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) : 3830 - 3835
[6] THE MOLECULAR-GENETICS OF CANCER
BISHOP, JM
[J]. SCIENCE, 1987, 235 (4786) : 305 - 311
[7] Blaskovich MA, 2003, CANCER RES, V63, P1270
[8] Oncogenic kinase signalling
Blume-Jensen, P
Hunter, T
[J]. NATURE, 2001, 411 (6835) : 355 - 365
[9] Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
Bowman, T
Broome, MA
Sinibaldi, D
Wharton, W
Pledger, WJ
Sedivy, JM
Irby, R
Yeatman, T
Courtneidge, SA
Jove, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (13) : 7319 - 7324
[10] STATs in oncogenesis
Bowman, T
Garcia, R
Turkson, J
Jove, R
[J]. ONCOGENE, 2000, 19 (21) : 2474 - 2488

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