Mitosis controls the Golgi and the Golgi controls mitosis

被引:81
作者
Colanzi, Antonino [1 ]
Corda, Daniela [1 ]
机构
[1] Consorzio Mario Negri Sud, Dept Cell Biol & Oncol, I-66030 Chieti, Italy
关键词
D O I
10.1016/j.ceb.2007.06.002
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In mammals, the Golgi complex is structured in the form of a continuous membranous system composed of up to 100 stacks connected by tubular bridges, the 'Golgi ribbon'. During mitosis, the Golgi undergoes extensive fragmentation through a multistage process that allows its correct partitioning and inheritance by daughter cells. Strikingly, this Golgi fragmentation is required not only for inheritance but also for mitotic entrance itself, since its block results in the arrest of the cell cycle in G2. This is called the 'Golgi mitotic checkpoint'. Recent studies have identified the severing of the ribbon into its constituent stacks during early G2 as the precise stage of Golgi fragmentation that controls mitotic entry. This opens new ways to elucidate the mechanism of the Golgi checkpoint.
引用
收藏
页码:386 / 393
页数:8
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