The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia

被引：126

作者：

Sawtell, NM ^{[1
]}

机构：

[1] Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 08期

关键词：

D O I：

10.1128/JVI.72.8.6888-6892.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The purpose of this study was to define the relationship between herpes simplex virus (HSV) latency and in vivo ganglionic reactivation. Groups of mice with numbers of latently infected neurons ranging from 1.9 to 24% were generated by varying the input titer of wild-type HSV type 1 strain 17syn+. Reactivation of the virus in mice from each group was induced by hyperthermic stress. The number of animals that exhibited virus reactivation was positively correlated with the number of latently infected neurons in the ganglia over the entire range examined (r = 0.9852, P < 0.0001 [Pearson correlation]).

引用

页码：6888 / 6892

页数：5

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