Anti-pseudomonal activity of collagen sponge with liposomal polymyxin B

被引：12

作者：

Trafny, EA

Grzybowski, J

OlszowskaGolec, M

Antos, M

Struzyna, J

机构：

[1] MIL INST HYG & EPIDEMIOL,DEPT MICROBIOL,PL-01163 WARSAW,POLAND

[2] MED ACAD WARSAW,DEPT PLAST SURG & BURNS,WARSAW,POLAND

来源：

PHARMACOLOGICAL RESEARCH | 1996年 / 33卷 / 01期

关键词：

liposomes; polymyxin B; Pseudomonas aeruginosa; infected wound;

D O I：

10.1006/phrs.1996.0010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An antibiotic delivery system has been developed using collagen sponge with liposome-encapsulated polymyxin B. Superficial, non-lethal infection was produced in mice by injecting Pseudomonas aeruginosa into the skin windows, Wounds were dressed with collagen sponge containing liposomal polymyxin B or containing empty liposomes (with PBS) as a control. Single dose of topically applied collagen sponge with encapsulated polymyxin B decreased bacterial cell number as compared to the control, Finally, after 8 days of experiment, the number of bacterial colonies dropped below 10(4) per biopsy, Presented polymyxin B delivery system offers potential clinical advantages. (C) 1996 The Italian Pharmacological Society

引用

页码：63 / 65

页数：3