Nucleotide sequence and phyogenetic classification of candidate human papilloma virus type 92

被引：32

作者：

Forslund, O ^{[1
]}

Antonsson, A

Higgins, G

Ly, H

Delius, H

Hunziker, A

de Villiers, EM

机构：

[1] Lund Univ, Malmo Univ Hosp, Dept Med Microbiol, SE-20502 Malmo, Sweden

[2] Inst Med & Vet Sci, Infect Dis Labs, Adelaide, SA 5000, Australia

[3] Deutsch Krebsforschungszentrum, Div Tumorvirus Characterizat, D-6900 Heidelberg, Germany

来源：

VIROLOGY | 2003年 / 312卷 / 02期

关键词：

HPV; NMSC; quantification; PCR; BCC; SCC; solar keratosis; complete genome;

D O I：

10.1016/S0042-6822(03)00391-X

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

From a basal cell carcinoma (BCC) the complete genome of candidate human papillomavirus (HPV) type 92 was characterized. Phylogenetically, the candidate HPV 92 was relatively distantly related to other cutaneous HPV types within the B1 group. By quantitative real time PCR, 94 viral copies were present per cell in the BCC and another BCC contained 1 viral copy per cell. Lower copy numbers were found in two solar keratoses (1 copy per 33 cells and 1 copy per 60 cells) and two squamous cell carcinomas (1 copy per 436 cells and 1 copy per 1143 cells). The high viral load of HPV 92 in two BCCs differs from the low amount of HPV DNA reported from nonmelanoma skin cancers. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：255 / 260

页数：6

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