Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer

被引:367
作者
Yoshizawa, K
Willett, WC
Morris, SJ
Stampfer, MJ
Spiegelman, D
Rimm, EB
Giovannucci, E
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Cambridge, MA 02138 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Cambridge, MA 02138 USA
来源
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 1998年 / 90卷 / 16期
关键词
D O I
10.1093/jnci/90.16.1219
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: In a recent randomized intervention trial, the risk of prostate cancer for men receiving a daily supplement of 200 mu g selenium was one third of that for men receiving placebo. By use of a nested case-control design within a prospective study, i,e., the Health Professionals Follow-Up Study, we investigated the association between risk of prostate cancer and prediagnostic level of selenium in toenails, a measure of long-term selenium intake. Methods: In 1986, 51529 male health professionals aged 40-75 years responded to a mailed questionnaire to form the prospective study. In 1987, 33737 cohort members provided toenail clippings. In 1988, 1990, 1992, and 1994, follow-up questionnaires were mailed. From 1989 through 1994, 181 new cases of advanced prostate cancer were reported. Case and control subjects were matched by age, smoking status, and month of toenail return. Selenium levels were determined by neutron activation. All P values are two-sided. Results: The selenium level in toenails varied substantially among men, with quintile medians ranging from 0.66 to 1.14 mu g/g for control subjects. When matched case-control data were analyzed, higher selenium levels were associated with a reduced risk of advanced prostate cancer (odds ratio [OR] for comparison of highest to lowest quintile = 0.49; 95% confidence interval [CI] = 0.25-0.96; P for trend .11), After additionally controlling for family history of prostate cancer, body mass index, calcium intake, lycopene intake, saturated fat intake, vasectomy, and geographical region, the OR was 0.35 (95 % CI = 0.16-0.78; P for trend =.03), Conclusions: Our results support earlier findings that higher selenium intakes may reduce the risk of prostate cancer. Further prospective studies and randomized trials of this relationship should be conducted.
引用
收藏
页码:1219 / 1224
页数:6
相关论文
共 36 条
[1]  
Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group, 1994, N Engl J Med, V330, P1029, DOI 10.1056/NEJM199404143301501
[2]  
[Anonymous], MICRONUTRIENTS AGR
[3]   THE ANALYSIS OF HUMAN NAILS FOR 24 ELEMENTS VIA K(0) AND CYCLIC NEUTRON-ACTIVATION ANALYSIS [J].
CHENG, TP ;
MORRIS, JS ;
KOIRTYOHANN, SR ;
SPATE, VL ;
BASKETT, CK .
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 1994, 353 (1-3) :457-460
[4]   NUTRITIONAL INFLUENCE ON CELLULAR ANTIOXIDANT DEFENSE SYSTEMS [J].
CHOW, CK .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1979, 32 (05) :1066-1081
[5]  
Clark LC, 1998, BRIT J UROL, V81, P730
[6]   Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin a randomized controlled trial - A randomized controlled trial [J].
Clark, LC ;
Combs, GF ;
Turnbull, BW ;
Slate, EH ;
Chalker, DK ;
Chow, J ;
Davis, LS ;
Glover, RA ;
Graham, GF ;
Gross, EG ;
Krongrad, A ;
Lesher, JL ;
Park, HK ;
Sanders, BB ;
Smith, CL ;
Taylor, JR .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (24) :1957-1963
[7]  
Clark LC, 1997, JAMA-J AM MED ASSOC, V277, P1520
[8]   SERUM LEVELS OF SELENIUM AND RETINOL AND THE SUBSEQUENT RISK OF CANCER [J].
COATES, RJ ;
WEISS, NS ;
DALING, JR ;
MORRIS, JS ;
LABBE, RF .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1988, 128 (03) :515-523
[9]  
COMBS GF, 1984, ANNU REV NUTR, V4, P257, DOI 10.1146/annurev.nu.04.070184.001353
[10]  
COMBS GF, 1985, NUTR REV, V43, P325, DOI 10.1111/j.1753-4887.1985.tb02392.x