Cr(Salen)-catalyzed addition of 1,3-dichloropropene to aromatic aldehydes, a simple access to optically active vinyl epoxides

被引：36

作者：

Bandini, M ^{[1
]}

Cozzi, PG ^{[1
]}

Melchiorre, P ^{[1
]}

Morganti, S ^{[1
]}

Umani-Ronchi, A ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 08期

关键词：

D O I：

10.1021/ol015597h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral Cr(Salen) complex (1) prepared in situ from CrCl3 promotes the enantioselective addition of 1,3-dichloropropene to aromatic aldehydes in the presence of Mn as the stoichiometric reductant and Me3SiCl as a scavenger. The resulting 1,2-chlorohydrins obtained in good enantiomeric and diastereoisomeric excesses can be easily transformed into the corresponding chiral vinyl epoxides.

引用

页码：1153 / 1155

页数：3

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