Two complimentary methods for the synthesis of the terminal N-alkenyl-N-methylformamide group found in cytotoxic marine macrolides

被引：28

作者：

Paterson, I

Cowden, C

Watson, C

机构：

[1] University Chemical Laboratory, Cambridge CB2 1EW, Lensfield Road

来源：

SYNLETT | 1996年 / 03期

关键词：

Wittig reaction; phosphorus pentoxide; N-methylformamide; condensation; scytophycin;

D O I：

10.1055/s-1996-5383

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two complimentary methods for the synthesis of trans-N-alkenyl-N-methylformamides from aldehydes are described. Method A involves condensation with MeNHCHO using P2O5, while Method B employs a Wittig reaction with 5 followed by Iz-catalysed alkene isomerisation.

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页码：209 / &

页数：4

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