Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones

被引：155

作者：

Takei, K ^{[1
]}

Shin, RM

Inoue, T

Kato, K

Mikoshiba, K

机构：

[1] Japan Sci & Technol Corp, ERATO, Calciosignal Net Project, Bunkyo Ku, Tokyo 1130021, Japan

[2] Univ Tokyo, Inst Med Sci, Dept Mol Neurobiol, Minato Ku, Tokyo 1080071, Japan

[3] RIKEN, Brain Sci Inst, Wako, Saitama 3510198, Japan

来源：

SCIENCE | 1998年 / 282卷 / 5394期

关键词：

D O I：

10.1126/science.282.5394.1705

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R(IP(3)R1) is enriched in growth cones of neurons in chick dorsal root ganglia. Depletion of internal Ca2+ stores and inhibition of IP3 signaling with drugs inhibited neurite extension. Microinjection of. heparin, a competitive IP3R blocker, induced neurite retraction. Acute Localized Loss of function of IP(3)R1 in the growth cone induced by chromophore-assisted Laser inactivation resulted in growth arrest and neurite retraction. IP3-induced Ca2+ release in growth cones appears to have a crucial role in control of nerve growth.

引用

页码：1705 / 1708

页数：4

共 26 条

[1]

AIHARA Y, UNPUB

[2] NEURAL AND DEVELOPMENTAL ACTIONS OF LITHIUM - A UNIFYING HYPOTHESIS [J].

BERRIDGE, MJ ;

DOWNES, CP ;

HANLEY, MR .

CELL, 1989, 59 (03) :411-419

[3] ASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL INACTIVATION OF CALCINEURIN [J].

CHANG, HY ;

TAKEI, K ;

SYDOR, AM ;

BORN, T ;

RUSNAK, F ;

JAY, DG .

NATURE, 1995, 376 (6542) :686-690

[4]

CYPHER C, 1992, Current Opinion in Cell Biology, V4, P4, DOI 10.1016/0955-0674(92)90051-D

[5]

Doherty Patrick, 1994, Current Opinion in Neurobiology, V4, P49, DOI 10.1016/0959-4388(94)90031-0

[6] PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF THE INOSITOL 1,4,5-TRISPHOSPHATE-BINDING PROTEIN-P400 [J].

FURUICHI, T ;

YOSHIKAWA, S ;

MIYAWAKI, A ;

WADA, K ;

MAEDA, N ;

MIKOSHIBA, K .

NATURE, 1989, 342 (6245) :32-38

[7]

FURUICHI T, 1993, RECEPTOR CHANNEL, V1, P11

[8] CHARACTERIZATION OF SPONTANEOUS CALCIUM TRANSIENTS IN NERVE GROWTH CONES AND THEIR EFFECT ON GROWTH CONE MIGRATION [J].

GOMEZ, TM ;

SNOW, DM ;

LETOURNEAU, PC .

NEURON, 1995, 14 (06) :1233-1246

[9] DEVELOPMENTAL MECHANISMS THAT GENERATE PRECISE PATTERNS OF NEURONAL CONNECTIVITY [J].

GOODMAN, CS ;

SHATZ, CJ .

CELL, 1993, 72 :77-98

[10]

GOSHIMA Y, 1993, J NEUROSCI, V13, P559

← 1 2 3 →