Pathogenesis and prenatal diagnosis of human cytomegalovirus infection

被引:100
作者
Revello, MG [1 ]
Gerna, G [1 ]
机构
[1] IRCCS Policlin San Matteo, Serv Virol, Pavia, Italy
关键词
human cytomegalovirus; prenatal diagnosis; pathogenesis; fetal infection;
D O I
10.1016/j.jcv.2003.09.012
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Congenital human cytomegalovirus (HCMV) infection is the leading infectious cause of mental retardation and sensorineural deafness. Intrauterine transmission and adverse outcome are mainly related to primary maternal infection. Mechanisms of intrauterine transmission are slowly being unraveled and compelling evidence of the importance of using HCMV clinical strains rather than laboratory-adapted strains for in vitro studies is growing. In the absence of a vaccine or a specific antiviral therapy which could be safely administered to pregnant women with primary HCMV infection, the option of prenatal diagnosis has a crucial role in the management of pregnancy complicated by primary HCMV infection. Reliability of prenatal results, however, is still a major concern presenting the risk of either false-negative or false-positive results. However, as more light is shed on the natural history of HCMV infection during pregnancy and fetal life, the predictive value of negative prenatal diagnosis results is becoming more defined, thus improving the quality of counseling. In addition, the availability of different assays for detection of HCMV in both fetal blood and amniotic fluid samples will eventually reduce the risk of false-positive results. Finally, the identification of reliable prognostic markers of fetal disease remains the ultimate goal and a major challenge. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:71 / 83
页数:13
相关论文
共 73 条
[1]  
AHMADZALMAY A, 2001, OBSTET GYNECOL, V97, P443
[2]  
Bodéus M, 1999, PRENATAL DIAG, V19, P314, DOI 10.1002/(SICI)1097-0223(199904)19:4<314::AID-PD542>3.0.CO
[3]  
2-H
[4]   Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity. [J].
Boppana, SB ;
Rivera, LB ;
Fowler, KB ;
Mach, M ;
Britt, WJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (18) :1366-1371
[5]   Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains [J].
Cha, TA ;
Tom, E ;
Kemble, GW ;
Duke, GM ;
Mocarski, ES ;
Spaete, RR .
JOURNAL OF VIROLOGY, 1996, 70 (01) :78-83
[6]   Ultrasound and fetal diagnosis of perinatal infection [J].
Crino, JP .
CLINICAL OBSTETRICS AND GYNECOLOGY, 1999, 42 (01) :71-80
[7]   INTRAUTERINE DIAGNOSIS OF CYTOMEGALOVIRUS INFECTION - VIRAL RECOVERY FROM AMNIOCENTESIS FLUID [J].
DAVIS, LE ;
TWEED, GV ;
CHIN, TDY ;
MILLER, GL .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1971, 109 (08) :1217-+
[8]   ACCURACY OF AMNIOTIC-FLUID TESTING BEFORE 21 WEEKS GESTATION IN PRENATAL-DIAGNOSIS OF CONGENITAL CYTOMEGALOVIRUS-INFECTION [J].
DONNER, C ;
LIESNARD, C ;
BRANCART, F ;
RODESCH, F .
PRENATAL DIAGNOSIS, 1994, 14 (11) :1055-1059
[9]  
DONNER C, 1993, OBSTET GYNECOL, V82, P481
[10]   Prenatal diagnosis of congenital cytomegalovirus infection in 189 pregnancies with known outcome [J].
Enders, G ;
Bäder, U ;
Lindemann, L ;
Schalasta, G ;
Daiminger, A .
PRENATAL DIAGNOSIS, 2001, 21 (05) :362-377