Behavioral reactivity to novelty during youth as a predictive factor of stress-induced corticosterone secretion in the elderly - A life-span study in rats

被引：52

作者：

Dellu, F ^{[1
]}

Mayo, W ^{[1
]}

Vallee, M ^{[1
]}

Maccari, S ^{[1
]}

Piazza, PV ^{[1
]}

LeMoal, M ^{[1
]}

Simon, H ^{[1
]}

机构：

[1] UNIV BORDEAUX 2,INSERM U259,LAB PSYCHOBIOL COMPORTEMENTS ADAPTATIFS,F-33077 BORDEAUX,FRANCE

来源：

PSYCHONEUROENDOCRINOLOGY | 1996年 / 21卷 / 05期

关键词：

aging; HPA axis; inter- and intra-individual differences; novelty-induced locomotion; longitudinal study; rat;

D O I：

10.1016/0306-4530(96)00017-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inter- and intra-individual differences in hypothalamo-pituitary adrenal (HPA) axis activity and behavioral reactivity to novelty between young and old rats were evidenced in this longitudinal life-span study. Higher responders to novelty (HR) had a higher corticosterone secretion which showed a quicker increase with age than did the others (LR); the differences in response to novelty observed in youth were no longer apparent in the old rats. Response to novelty in youth is a predictive factor of accelerated aging of the HPA axis. These early changes, which precede the appearance of the memory deficits, may be a causal factor. Disappearance of behavioral and endocrinological inter-individual differences at 21 months highlights the importance of not restricting aging studies to old subjects. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：441 / 453

页数：13

共 35 条

[1]

[Anonymous], HDB BIOL AGING

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