Wnt signaling pathway and lung disease

被引：96

作者：

Van Scoyk, Michelle

Randall, Jessica

Sergew, Amen

Williams, Lisa M.

Tennis, Meredith

Winn, Robert A.

机构：

[1] Univ Colorado, Dept Med, Denver, CO USA

[2] Univ Colorado, Hlth Sci Ctr, Denver, CO USA

[3] Vet Adm Med Ctr, Denver, CO USA

来源：

TRANSLATIONAL RESEARCH | 2008年 / 151卷 / 04期

关键词：

D O I：

10.1016/j.trsl.2007.12.011

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 [基础医学];

摘要：

The Wnt pathway plays an important role in development and in regulating adult stem cell systems. A variety of cellular processes is mediated by Wnt signaling, which includes cellular proliferation, differentiation, survival, apoptosis, and cell motility. Loss of regulation of these pathways can lead to tumorigenesis, and the Wnt pathway has been implicated in the development of several types of cancers, including colon, lung, leukemia, breast, thyroid, and prostate. The Wnt pathway has also been associated with other lung diseases such as interstitial lung disease (ILD) and asthma. Our increasing understanding of the Wnt pathway offers great hope that new molecular-based screening tests and pharmaceutical agents that selectively target this pathway will be developed to diagnose and treat these diseases in the future.

引用

收藏

页码：175 / 180

页数：6

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