Ebolavirus and Marburgvirus:: Insight the Filoviridae family

被引：63

作者：

Ascenzi, Paolo ^{[1
]}

Bocedi, Alessio ^{[1
]}

Heptonstall, Julia ^{[1
]}

Capobianchi, Maria Rosaria ^{[1
]}

Di Caro, Antonino ^{[1
]}

Mastrangelo, Eloise ^{[2
,3
]}

Bolognesi, Martino ^{[2
,3
]}

Ippolito, Giuseppe ^{[1
]}

机构：

[1] IRCCS, Natl Inst Infect Dis, I-00149 Rome, Italy

[2] Univ Milan, CNR, INFM, I-20131 Milan, Italy

[3] Univ Milan, Dept Biomol Sci & Biotechnol, I-20131 Milan, Italy

来源：

MOLECULAR ASPECTS OF MEDICINE | 2008年 / 29卷 / 03期

关键词：

Ebolavirus; Marburgvirus; viral genome; viral proteins; lethal haemorrhagic fever; infection; epidemiology; pathogenesis; clinical features and management; prevention and control; therapy; vaccine; biodefence;

D O I：

10.1016/j.mam.2007.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins. No significant homology is observed between filovirus proteins and any known macromolecule. Moreover, Marburgvirus and Ebolavirus show significant differences in protein homology. The natural maintenance cycle of filoviruses is unknown, the natural reservoir, the mode of transmission, the epidemic disease generation, and temporal dynamics are unclear. Lastly, Ebolavirus and Marburgvirus are considered as potential biological weapons. Vaccine appears the unique therapeutic frontier. Here, molecular and clinical aspects of filoviral haemorrhagic fevers are summarized. (c) 2007 Published by Elsevier Ltd.

引用

页码：151 / 185

页数：35

共 236 条

[1] Ebola virus glycoprotein GP is not cytotoxic when expressed constitutively at a moderate level [J].