Radiologic screening for lung cancer. present status and future perspectives.

被引:11
作者
Diederich, S [1 ]
Wormanns, D [1 ]
Heindel, W [1 ]
机构
[1] Univ Munster, Inst Klin Radiol, D-4400 Munster, Germany
来源
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN | 2001年 / 173卷 / 10期
关键词
lung nodule; lung neoplasm; diagnosis; cancer screening; computed tomography;
D O I
10.1055/s-2001-17578
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Lung cancer is the most common cause of death from malignancy. This is predominantly due to the poor prognosis of the mostly advanced tumor stages at the time of presentation. Prognosis of early, usually asymptomatic stages is more favourable, particularly in non-small-cell histologic types. Therefore, early detection using diagnostic tests promises reduction of mortality from lung cancer. Due to its high sensitivity for small pulmonary nodules-the most common manifestation of early lung cancer-computed tomography appears suitable as a screening test particularly as the high radiation exposure associated with standard examination protocols can be significantly reduced for this purpose. Due to the high prevalence of benign small pulmonary nodules diagnostic algorithms are required for non-invasive classification of detected nodules. Preliminary studies of low-dose CT using algorithms based on size and density of detected nodules revealed a high proportion of asymptomatic lung cancers and early resectable tumor stages with a small number of invasive procedures for benign nodules. Prior to a wide application of this technique in clinical routine more data is required as to appropriate inclusion criteria, screening intervals and most importantly the effect of screening on reduction of mortality from lung cancer.
引用
收藏
页码:873 / 882
页数:10
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