The effect of long term oestradiol implantation on bone mineral density in postmenopausal women who have undergone hysterectomy and bilateral oophorectomy

被引：31

作者：

Wahab, M

Ballard, P

Purdie, DW

Cooper, A

Willson, JC

机构：

[1] HULL ROYAL INFIRM, CTR METAB BONE DIS, KINGSTON UPON HULL HU3 2RW, N HUMBERSIDE, ENGLAND

[2] PRINCESS ROYAL HOSP, DEPT OBSTET & GYNAECOL, KINGSTON UPON HULL, N HUMBERSIDE, ENGLAND

来源：

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 1997年 / 104卷 / 06期

关键词：

D O I：

10.1111/j.1471-0528.1997.tb11985.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Twelve women who had received oestradiol implantation on demand for at least 15 years following hysterectomy with bilateral oophorectomy, underwent bone densitometry of hip and spine. Bone mass of hip and spine was significantly elevated above that of both the age matched mean to a degree hitherto undocumented. This suggests that oestrogen in high doses or over a long period may produce a true anabolic effect on bone mass.

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页码：728 / 731

页数：4

相关论文

共 10 条

[1] THE EFFECTS OF SUBCUTANEOUS HORMONE IMPLANTS DURING THE CLIMACTERIC [J].

CARDOZO, L ;

GIBB, DMF ;

TUCK, SM ;

THOM, MH ;

STUDD, JWW ;

COOPER, DJ .

MATURITAS, 1984, 5 (03) :177-184

[2] SYMPTOMS OF ESTROGEN DEFICIENCY ASSOCIATED WITH SUPRAPHYSIOLOGICAL PLASMA ESTRADIOL CONCENTRATIONS IN WOMEN WITH ESTRADIOL IMPLANTS [J].

GANGAR, K ;

CUST, M ;

WHITEHEAD, MI .

BRITISH MEDICAL JOURNAL, 1989, 299 (6699) :601-602

[3]

GARNETT T, 1991, OBSTET GYNECOL, V78, P1002

[4] INCREASE IN BONE MASS OF OLDER POSTMENOPAUSAL WOMEN WITH LOW MINERAL BONE-DENSITY AFTER ONE-YEAR OF PERCUTANEOUS ESTRADIOL IMPLANTS [J].

HOLLAND, EFN ;

LEATHER, AT ;

STUDD, JWW .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1995, 102 (03) :238-242

[5]

LINDSAY R, 1976, LANCET, V1, P1038

[6] OSTEOPOROSIS AND THE RISK OF HIP FRACTURE [J].

MELTON, LJ ;

WAHNER, HW ;

RICHELSON, LS ;

OFALLON, WM ;

RIGGS, BL .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1986, 124 (02) :254-261

[7] MAINTAINED BONE-DENSITY AT ADVANCED AGES AFTER LONG-TERM TREATMENT WITH LOW-DOSE ESTRADIOL IMPLANTS [J].

NAESSEN, T ;

PERSSON, I ;

THOR, L ;

MALLMIN, H ;

LJUNGHALL, S ;

BERGSTROM, R .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1993, 100 (05) :454-459

[8] INCREASE IN BONE MASS AFTER ONE YEAR OF PERCUTANEOUS ESTRADIOL AND TESTOSTERONE IMPLANTS IN POSTMENOPAUSAL WOMEN WHO HAVE PREVIOUSLY RECEIVED LONG-TERM ORAL ESTROGENS [J].

SAVVAS, M ;

STUDD, JWW ;

NORMAN, S ;

LEATHER, AT ;

GARNETT, TJ ;

FOGELMAN, I .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1992, 99 (09) :757-760

[9] THE RELATIONSHIP BETWEEN PLASMA ESTRADIOL AND THE INCREASE IN BONE-DENSITY IN POSTMENOPAUSAL WOMEN AFTER TREATMENT WITH SUBCUTANEOUS HORMONE IMPLANTS [J].

STUDD, J ;

SAVVAS, M ;

WASTON, N ;

GARNETT, T ;

FOGELMAN, I ;

COOPER, D .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 163 (05) :1474-1479

[10]

WHITEHEAD M, 1992, HORMONE REPLACEMENT