Intracerebroventricularly transplanted embryonic neuronal tissue from inflammatory-resistant F344/N rats decreases acoustic startle responses in inflammatory-susceptible LEW/N rats

被引：6

作者：

Misiewicz, B ^{[1
]}

Poltorak, M ^{[1
]}

Gomez, M ^{[1
]}

Glowa, JR ^{[1
]}

Gold, PW ^{[1
]}

Sternberg, EM ^{[1
]}

机构：

[1] NEUROPSYCHIAT BRANCH,WASHINGTON,DC 20032

来源：

CELL TRANSPLANTATION | 1996年 / 5卷 / 02期

关键词：

acoustic startle response; hypothalamus; neural transplantation; inflammation; stress;

D O I：

10.1016/0963-6897(95)02027-6

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Recently, we have shown that intracerebral transplantation of fetal F344/N hypothalamic tissue into LEW/N rats converts the LEW/N inflammatory-susceptible phenotype into an inflammatory-resistant phenotype in LEW/N hosts, Because LEW/N rats also exhibit relatively high acoustic startle responses (ASRs) compared to F344/N rats, in the present study we examined the effects on ASR of transplantation of F344/N hypothalamic tissue into the third ventricle of LEW/N rats, Dissected neuronal tissue from F344/N rats (Day E15-16) was implanted into the third ventricle of LEW/N rats, After 4 wk of postoperative survival, the animals' responses to acoustic startle stimuli were tested. Compared to naive and sham-operated animals, LEW/N rats transplanted with hypothalamic tissue exhibited significant decreases in ASR amplitudes, A similar decrease in ASR amplitude was observed in the group of LEW/N rats transplanted with embryonic striatal tissue, Our results indicate that the third ventricular neuronal grafts may modulate behavioral responses in the LEW/N rats. Although the mechanism of this effect is unknown, these studies suggest that intracerebral neuronal transplantation is a viable method with which to explore mechanisms of behavioral, neuroendocrine, and inflammatory response associations.

引用

页码：287 / 291

页数：5

共 27 条

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