Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging

被引：140

作者：

Adams, Peter D. ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

来源：

GENE | 2007年 / 397卷 / 1-2期

关键词：

HIRA; ASF1a; SAHF; senescence; cancer;

D O I：

10.1016/j.gene.2007.04.020

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Cellular senescence is an important tumor suppression process, and a possible contributor to tissue aging. Senescence is accompanied by extensive changes in chromatin structure. In particular, many senescent cells accumulate specialized domains of facultative heterochromatin, called senescence-Associated Heterochromatin Foci (SAHF), which are thought to repress expression of proliferation-promoting genes, thereby contributing to senescence-associated proliferation arrest. This article reviews our current understanding of the structure, assembly and function of these SAHF at a cellular level. The possible contribution of SAHF to tumor suppression and tissue aging is also critically discussed. (C) 2007 Elsevier B.V. All rights reserved.

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收藏

页码：84 / 93

页数：10

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