Design and synthesis of novel antibacterial peptide-resin conjugates

被引：48

作者：

Cho, Won-Mi ^{[1
]}

Joshi, Bishnu Prasad ^{[1
]}

Cho, Hyeongjin ^{[1
]}

Lee, Keun-Hyeung ^{[1
]}

机构：

[1] Inha Univ, Dept Chem, Chem Bioorgan Lab, Inchon 402751, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 21期

关键词：

antibacterial activity; immobilization; beta-sheet; antimicrobial peptide; conjugation; resin;

D O I：

10.1016/j.bmcl.2007.08.056

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We synthesized a novel peptide-resin conjugate by immobilizing beta-sheet antibacterial peptide on PEG-PS resin. The peptide-resin conjugate, similar to cationic antimicrobial peptides, demonstrated unique properties such as potent antibacterial activity, no hemolytic activity, lipid membrane perturbation activity, and potent synergism with vancomycin. Specially, the peptide-resin conjugate showed a more increased lipid membrane perturbation activity in comparison to unbound beta-sheet antibacterial peptide. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：5772 / 5776

页数：5

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