Reduction of Coxiella burnetii Prevalence by Vaccination of Goats and Sheep, the Netherlands

被引：106

作者：

Hogerwerf, Lenny ^{[1
]}

van den Brom, Rene ^{[2
]}

Roest, Hendrik I. J. ^{[3
]}

Bouma, Annemarie

Vellema, Piet ^{[2
]}

Pieterse, Maarten

Dercksen, Daan ^{[2
]}

Nielen, Mirjam

机构：

[1] Univ Utrecht, Fac Vet Med, Dept Farm Anim Hlth, NL-3584 CL Utrecht, Netherlands

[2] Anim Hlth Serv, Deventer, Netherlands

[3] Wageningen UR, Cent Vet Inst, Lelystad, Netherlands

来源：

EMERGING INFECTIOUS DISEASES | 2011年 / 17卷 / 03期

关键词：

Q-FEVER; OUTBREAK;

D O I：

10.3201/eid1703.101157

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, the number of human Q fever cases in the Netherlands increased dramatically. In response to this increase, dairy goats and dairy sheep were vaccinated against Coxiella burnetii. All pregnant dairy goats and dairy sheep in herds positive for Q fever were culled. We identified the effect of vaccination on bacterial shedding by small ruminants. On the day of culling, samples of uterine fluid, vaginal mucus, and milk were obtained from 957 pregnant animals in 13 herds. Prevalence and bacterial load were reduced in vaccinated animals compared with unvaccinated animals. These effects were most pronounced in animals during their first pregnancy. Results indicate that vaccination may reduce bacterial load in the environment and human exposure to C. burnetii.

引用

页码：379 / 386

页数：8

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