Type 1 diabetes is associated with increased cyclooxygenase- and cytokine-mediated inflammation

被引:70
作者
Basu, S
Vessby, B
Larsson, A
Berne, C
Vessby, J
机构
[1] Uppsala Univ, Sect Geriatr & Clin Nutr Res, Fac Med, SE-75125 Uppsala, Sweden
[2] Uppsala Univ, Sect Clin Chem, Uppsala, Sweden
[3] Uppsala Univ, Sect Internal Med, Fac Med, Uppsala, Sweden
关键词
D O I
10.2337/diacare.28.6.1371
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE - The extent of involvement of cyclooxygenase (COX)-mediated inflammation in type 1 diabetes is unknown, and the association between the COX- and cytokine-mediated inflammatory responses in type I diabetes is not fully understood. RESEARCH DESIGN AND METHODS - Plasma high-sensitivity C-reactive protein (CRP), 24-h urinary and plasma 15-keto-dihydro-prostaglandin F-2 alpha (a metabolite of prosiaglandin F-2 alpha [PGF(2 alpha)] and an indicator of COX-mediated inflammation), serum amyloid protein A (SAA), and interleukin (IL)-6 (indicators of inflammation) were measured in 38 subjects with type 1 diabetes and 41 healthy age- and sex-matched control subjects. RESULTS - The inflammatory indicators (urinary 15-keto-dihydro-PGF(2 alpha), P < 0.01; IL-6, P < 0.04) were increased in men with diabetes. CRP and SAA did not show any significant difference between the diabetic and the control subjects. Urinary levels of 15-keto-dihydroPGF(2 alpha) correlated with the degree of glycemic control, HbA(1c) (r = 0.42, P < 0.0005). No correlation was found between the duration of diabetes and the inflammatory biomarkers or metabolic measurements. CONCLUSIONS - These results suggest that an early low-grade inflammatory process reflected by elevated levels of PGF(2 alpha) and IL-6 is involved in type 1 diabetes. Thus, both COX- and cytokine-mediated inflammatory pathways are significantly related to type I diabetes.
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页码:1371 / 1375
页数:5
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