Drug effects on spermatogenesis

被引:17
作者
Amory, John K. [1 ]
机构
[1] Univ Washington, Res Ctr Reprod & Contracept, Dept Med, Seattle, WA 98195 USA
关键词
D O I
10.1358/dot.2007.43.10.1131829
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Many drugs can adversely affect spermatogenesis. These effects can occur either by directly inhibiting sperm or testicular function or indirectly by impairing the hypothalamic pituitary testicular axis. In this paper, we will review the drugs that are known to adversely impact spermatogenesis, and/or sperm function and detail what is known about the mechanisms through which these compounds impair fertility in men. (c) 2007 Prous Science. All rights reserved.
引用
收藏
页码:717 / 724
页数:8
相关论文
共 63 条
[1]   Expression and localization of δ-, κ-, and μ-opioid receptors in human spermatozoa and implications for sperm motility [J].
Agirregoitia, Ekaitz ;
Valdivia, Asier ;
Carracedo, Arkaitz ;
Casis, Luis ;
Gil, Javier ;
Subiran, Nerea ;
Ochoa, Carmen ;
Irazusta, Jon .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (12) :4969-4975
[2]   Endocrine regulation of testicular function in men: implications for contraceptive development [J].
Amory, JK ;
Bremner, W .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2001, 182 (02) :175-179
[3]   The effect of 5α reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men [J].
Amory, John K. ;
Wang, Christina ;
Swerdloff, Ronald S. ;
Anawalt, Bradley D. ;
Matsumoto, Alvin M. ;
Bremner, William J. ;
Walker, Susan E. ;
Haberer, Lynda J. ;
Clark, Richard V. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (05) :1659-1665
[4]   Cryopreservation of sperm: Indications, methods and results [J].
Anger, JT ;
Gilbert, BR ;
Goldstein, M .
JOURNAL OF UROLOGY, 2003, 170 (04) :1079-1084
[5]  
[Anonymous], 1999, WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction
[6]  
Braunstein G D, 1978, Infertility, V1, P33
[7]  
Enders G, 1997, J Am Board Fam Pract, V10, P131
[8]   Drug Insight: clinical use of agonists and antagonists of luteinizing-hormone-releasing hormone [J].
Engel, Joerg B. ;
Schally, Andrew V. .
NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, 2007, 3 (02) :157-167
[9]   Cetrorelix in the treatment of female infertility and endometriosis [J].
Finas, Dominique ;
Hornung, Daniela ;
Diedrich, Klaus ;
Schultze-Mosgau, Askan .
EXPERT OPINION ON PHARMACOTHERAPY, 2006, 7 (15) :2155-2168
[10]  
FRIBERG L, 1974, CADMIUM ENV, P37