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Evolutionary diversification of mitochondrial proteomes: implications for human disease

被引：54
作者：
Richly, E
Chinnery, PF
Leister, D
机构：
[1] Max Planck Inst Zuchtungsforsch, Abt Pflanzenzuchtung & Ertragsphysiol, D-50829 Cologne, Germany
[2] Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
TRENDS IN GENETICS | 2003年 / 19卷 / 07期
关键词：
SUBCELLULAR-LOCALIZATION; GENOME SEQUENCE; PROTEINS; GENES; ARABIDOPSIS; ORIGIN;
D O I：
10.1016/S0168-9525(03)00137-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
By combining comparative genomics and computational identification of protein targeting, we predicted the size and composition of the mitochondrial proteome for ten species. Functional mitochondria could harbour from a few hundred to more than 3000 gene products, and protein relocation from and to mitochondria occurred during evolution. Although each genome studied contains lineage-specific mitochondrial proteins, conserved mitochondrial proteins also exist. Their functions mostly relate to transport and metabolism, and in humans their mutated states are frequently associated with disease.
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收藏
页码：356 / 362
页数：7
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