Aging of the innate immune system

被引：468

作者：

Shaw, Albert C. ^{[1
]}

Joshi, Samit ^{[1
]}

Greenwood, Hannah ^{[2
]}

Panda, Alexander ^{[1
]}

Lord, Janet M. ^{[2
]}

机构：

[1] Yale Univ, Infect Dis Sect, Dept Internal Med, Sch Med, New Haven, CT 06520 USA

[2] Univ Birmingham, MRC Ctr Immune Regulat, Sch Immun & Infect, Birmingham B15 2TT, W Midlands, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

DENDRITIC CELLS; INFLAMMATORY RESPONSE; CYTOKINE PRODUCTION; UP-REGULATION; AGED MICE; T-CELLS; EXPRESSION; INJURY; DYSREGULATION; DECREASE;

D O I：

10.1016/j.coi.2010.05.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The innate immune system is composed of a network of cells including neutrophils, NK and NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions with pathogens. Age-associated defects are observed in the activation of all of these cell types, linked to compromised signal transduction pathways including the Toll-like Receptors. However, aging is also characterized by a constitutive pro-inflammatory environment (inflamm-aging) with persistent low-grade innate immune activation that may augment tissue damage caused by infections in elderly individuals. Thus, immunosenescence in the innate immune system appears to reflect dysregulation, rather than exclusively impaired function.

引用

页码：507 / 513

页数：7

共 54 条

[1] Decreased TNF-α synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging [J].

Agius, Elaine ;

Lacy, Katie E. ;

Vukmanovic-Stejic, Milica ;

Jagger, Ann L. ;

Papageorgiou, Anna-Pia ;

Hall, Sue ;

Reed, John R. ;

Curnow, S. John ;

Fuentes-Duculan, Judilyn ;

Buckley, Christopher D. ;

Salmon, Mike ;

Taams, Leonie S. ;

Krueger, James ;

Greenwood, John ;

Klein, Nigel ;

Rustin, Malcolm H. A. ;

Akbar, Arne N. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (09) :1929-1940

[2] Altered innate immune functioning of dendritic cells in elderly humans: A role of phosphoinositide 3-kinase-signaling pathway [J].

Agrawal, Anshu ;

Agrawal, Sudhanshu ;

Cao, Jia-Ning ;

Su, Houfen ;

Osann, Kathryn ;

Gupta, Sudhir .

JOURNAL OF IMMUNOLOGY, 2007, 178 (11) :6912-6922

[3] Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA [J].

Agrawal, Anshu ;

Tay, Aa ;

Ton, Steven ;

Agrawal, Sudhanshu ;

Gupta, Sudhir .

JOURNAL OF IMMUNOLOGY, 2009, 182 (02) :1138-1145

[4] Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function [J].

Allen, Christopher D. C. ;

Cyster, Jason G. .

SEMINARS IN IMMUNOLOGY, 2008, 20 (01) :14-25

[5] Age-related changes in membrane lipid composition, fluidity and respiratory burst in rat peritoneal neutrophils [J].

Alvarez, E ;

Ruiz-Gutiérrez, V ;

Sobrino, F ;

Santa-María, C .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2001, 124 (01) :95-102

[6] Follicular dendritic cells in aging, a "bottle-neck" in the humoral immune response [J].

Aydar, Y ;

Balogh, P ;

Tew, JG ;

Szakal, AK .

AGEING RESEARCH REVIEWS, 2004, 3 (01) :15-29

[7] Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion [J].

Beerman, Isabel ;

Bhattacharya, Deepta ;

Zandi, Sasan ;

Sigvardsson, Mikael ;

Weissman, Irving L. ;

Bryder, David ;

Rossi, Derrick J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (12) :5465-5470

[8] Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression [J].

Boehmer, ED ;

Goral, J ;

Faunce, DE ;

Kovacs, EJ .

JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 75 (02) :342-349

[9] Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway [J].

Boehmer, ED ;

Meehan, MJ ;

Cutro, BT ;

Kovacs, EJ .

MECHANISMS OF AGEING AND DEVELOPMENT, 2005, 126 (12) :1305-1313

[10] Neutrophil extracellular traps kill bacteria [J].

Brinkmann, V ;

Reichard, U ;

Goosmann, C ;

Fauler, B ;

Uhlemann, Y ;

Weiss, DS ;

Weinrauch, Y ;

Zychlinsky, A .

SCIENCE, 2004, 303 (5663) :1532-1535

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