Demonstrating the intrinsic ion channel activity of virally encoded proteins

被引：31

作者：

Kelly, ML

Cook, JA

Brown-Augsburger, P

Heinz, BA

Smith, MC

Pinto, LH

机构：

[1] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA

[2] Wayne State Med Sch, Dept Physiol, Detroit, MI 48201 USA

[3] Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

FEBS LETTERS | 2003年 / 552卷 / 01期

关键词：

virus; viral ion channel; endogenous channel; influenza virus; rhinovirus;

D O I：

10.1016/S0014-5793(03)00851-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review summarizes the types of evidence that can be invoked in order to demonstrate that a virally encoded protein possesses ion channel activity that is intrinsic to the life cycle of the virus. Ion channel activity has been proposed to be a key step in the life cycle of influenza virus, and the protein responsible for this activity has been proposed to be the M2 protein encoded by the virus. This review contrasts the evidence supporting the conclusion that the A/M2 protein of influenza A virus has intrinsic ion channel activity with the evidence that the 3AB protein encoded by the human rhinovirus possesses intrinsic ion channel activity. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：61 / 67

页数：7

共 54 条

[1] AN AMPHIPATHIC PEPTIDE FROM THE C-TERMINAL REGION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS ENVELOPE GLYCOPROTEIN CAUSES PORE FORMATION IN MEMBRANES [J].