Bicontinuous, thermoresponsive, L3-phase silica nanocomposites and their smart drug-delivery applications

被引：40

作者：

Chang, JH ^{[1
]}

Shim, CH

Kim, BJ

Shin, Y

Exarhos, GJ

Kim, KJ

机构：

[1] Korea Inst Ceram Engn & Technol, Seoul 153801, South Korea

[2] Pacific NW Natl Lab, Richland, WA 99354 USA

来源：

ADVANCED MATERIALS | 2005年 / 17卷 / 05期

关键词：

D O I：

10.1002/adma.200400545

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bicontinuous, thermosensitive, L-3-phase silica nanocomposites are prepared by self-assembly of silicified L-3-phase silicates and L-3-phase silicates integrated with thermoresponsive poly(N-isopropylacryl amide) (PNIPAm; see Figure). In the L-3-PNIPAm material, interpenetrating nanoscale networks of silica and polymer gel are formed, with which highly controlled drug delivery is successfully demonstrated.

引用

页码：634 / +

页数：5

共 21 条

[1]

Chang JH, 2002, ADV MATER, V14, P378, DOI 10.1002/1521-4095(20020304)14:5<378::AID-ADMA378>3.0.CO

[2]

2-E

[3] CROSS-LINK DIMENSIONS IN GELATIN-POLY(ACRYLAMIDE) INTERPENETRATING HYDROGEL NETWORKS [J].

CHATTERJI, PR .

MACROMOLECULES, 1991, 24 (14) :4214-4215

[4] Volume phase transition in interpenetrating networks of poly(N-isopropylacrylamide) with gelatin [J].

Dhara, D ;

Rathna, GVN ;

Chatterji, PR .

LANGMUIR, 2000, 16 (06) :2424-2429

[5] Functionalized monolayers on ordered mesoporous supports [J].

Feng, X ;

Fryxell, GE ;

Wang, LQ ;

Kim, AY ;

Liu, J ;

Kemner, KM .

SCIENCE, 1997, 276 (5314) :923-926

[6] Alkaline lyotropic silicate-surfactant liquid crystals [J].

Firouzi, A ;

Atef, F ;

Oertli, AG ;

Stucky, GD ;

Chmelka, BF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (15) :3596-3610

[7] Correlation between the fluidity and topology of a sponge phase [J].

Gomati, R ;

Bouguerra, N ;

Gharbi, A .

PHYSICA B-CONDENSED MATTER, 2002, 322 (3-4) :262-269

[8] METAMORPHIC MATERIALS - RESTRUCTURING SILICEOUS MESOPOROUS MATERIALS [J].

KHUSHALANI, D ;

KUPERMAN, A ;

OZIN, GA ;

TANAKA, K ;

GARCES, J ;

OLKEN, MM ;

COOMBS, N .

ADVANCED MATERIALS, 1995, 7 (10) :842-&

[9] Ultrastable mesostructured silica vesicles [J].

Kim, SS ;

Zhang, WZ ;

Pinnavaia, TJ .

SCIENCE, 1998, 282 (5392) :1302-1305

[10]

KISHI R, 1991, POLYMER GELS, P205

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