Tumour-associated carbohydrate antigens in breast cancer

被引：189

作者：

Cazet, Aurelie ^{[1
,2
]}

Julien, Sylvain ^{[3
]}

Bobowski, Marie ^{[1
,2
]}

Burchell, Joy ^{[3
]}

Delannoy, Philippe ^{[1
,2
]}

机构：

[1] Univ Sci & Technol Lille, CNRS, UMR 8576, Struct & Funct Glycobiol Unit, F-59655 Villeneuve Dascq, France

[2] Univ Lille Nord France, F-59000 Lille, France

[3] Kings Coll London, Breast Canc Biol Grp, London SF1 9RT, England

来源：

BREAST CANCER RESEARCH | 2010年 / 12卷 / 03期

关键词：

SIALYL-TN ANTIGEN; NEUGC-CONTAINING GANGLIOSIDES; ARACHIS-HYPOGAEA AGGLUTININ; C-TYPE LECTIN; MONOCLONAL-ANTIBODY; LEWIS-X; PROGNOSTIC-SIGNIFICANCE; TISSUE DISTRIBUTION; E-SELECTIN; SIALYLTRANSFERASE EXPRESSION;

D O I：

10.1186/bcr2577

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival. Cellular models have shown the implication of these antigens in cell adhesion, migration, proliferation and tumour growth. The present review summarizes our current knowledge of glycosylation changes (structures, biosynthesis and occurrence) in breast cancer cell lines and primary tumours, and the consequences on disease progression and aggressiveness. The therapeutic strategies attempted to target tumour-associated carbohydrate antigens in breast cancer are also discussed.

引用

页数：13

共 103 条

[1] A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression [J].

Abd Hamid, Umi M. ;

Royle, Louise ;

Saldova, Radka ;

Radcliffe, Catherine M. ;

Harvey, David J. ;

Storr, Sarah J. ;

Pardo, Maria ;

Antrobus, Robin ;

Chapman, Caroline J. ;

Zitzmann, Nicole ;

Robertson, John F. ;

Dwek, Raymond A. ;

Rudd, Pauline M. .

GLYCOBIOLOGY, 2008, 18 (12) :1105-1118

[2] PROTEINASES AND SIALYLTRANSFERASE IN HUMAN-BREAST TUMORS [J].

ABECASSIS, J ;

COLLARD, R ;

EBER, M ;

PUSEL, J ;

FRICKER, JP ;

METHLIN, G .

INTERNATIONAL JOURNAL OF CANCER, 1984, 33 (06) :821-824

[3] Tn-syndrome [J].

Berger, EG .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1999, 1455 (2-3) :255-268

[4] Genes that mediate breast cancer metastasis to the brain [J].

Bos, Paula D. ;

Zhang, Xiang H. -F. ;

Nadal, Cristina ;

Shu, Weiping ;

Gomis, Roger R. ;

Nguyen, Don X. ;

Minn, Andy J. ;

van de Vijver, Marc J. ;

Gerald, William L. ;

Foekens, John A. ;

Massague, Joan .

NATURE, 2009, 459 (7249) :1005-U137

[5] PREDICTION OF LYMPH-NODE INVOLVEMENT IN BREAST-CANCER BY DETECTION OF ALTERED GLYCOSYLATION IN THE PRIMARY TUMOR [J].

BROOKS, SA ;

LEATHEM, AJC .

LANCET, 1991, 338 (8759) :71-74

[6]

Brooks SA, 2000, HISTOL HISTOPATHOL, V15, P143, DOI 10.14670/HH-15.143

[7] Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogene [J].

Buckhaults, P ;

Chen, L ;

Fregien, N ;

Pierce, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (31) :19575-19581

[8] Thomsen-Friedenreich-related carbohydrate antigens in normal adult human tissues: A systematic and comparative study [J].

Cao, Y ;

Stosiek, P ;

Springer, GF ;

Karsten, U .

HISTOCHEMISTRY AND CELL BIOLOGY, 1996, 106 (02) :197-207

[9] GD3 synthase overexpression enhances proliferation and migration of MDA-MB-231 breast cancer cells [J].

Cazet, Aurelie ;

Groux-Degroote, Sophie ;

Teylaert, Beatrice ;

Kwon, Kyung-Min ;

Lehoux, Sylvain ;

Slomianny, Christian ;

Kim, Cheorl-Ho ;

Le Bourhis, Xuefen ;

Delannoy, Philippe .

BIOLOGICAL CHEMISTRY, 2009, 390 (07) :601-609

[10] Expression of sialyi-Tn epitopes on β1 integrin alters epithelial cell phenotype, proliferation and haptotaxis [J].

Clément, M ;

Rocher, J ;

Loirand, G ;

Le Pendu, J .

JOURNAL OF CELL SCIENCE, 2004, 117 (21) :5059-5069

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