Synthesis of 6-aryl-2,4-diamino-pyrimidines and triazines using palladium catalysed Suzuki cross-coupling reactions

被引：50

作者：

Cooke, G ^{[1
]}

de Cremiers, HA

Rotello, VM

Tarbit, B

Vanderstraeten, PE

机构：

[1] Heriot Watt Univ, Dept Chem, Edinburgh EH14 4AS, Midlothian, Scotland

[2] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

[3] Seal Sands Chem Ltd, Middlesbrough TS2 1UB, Cleveland, England

来源：

TETRAHEDRON | 2001年 / 57卷 / 14期

基金：

英国工程与自然科学研究理事会; 美国国家科学基金会;

关键词：

triazines; Suzuki cross-coupling; tetrakis(triphenylphosphine)palladium; pyrimidines;

D O I：

10.1016/S0040-4020(01)00119-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The high yielding synthesis of 6-aryl-2,4-diaminopyrimidines and triazines via palladium catalysed Suzuki cross-coupling reactions of commercially available 6-chloro-2,4-diaminopyrimidine 1 or 6-chloro-2,4-diaminotriazine 8 and aryl boronic acids are described. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2787 / 2789

页数：3

共 11 条

[1] Hydrogen-bonded complexes of diaminopyridines and diaminotriazines: Opposite effect of acylation on complex stabilities
Beijer, FH
Sijbesma, RP
Vekemans, JAJM
Meijer, EW
Kooijman, H
Spek, AL
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (18) : 6371 - 6380
[2] Beijer FH, 1998, ANGEW CHEM INT EDIT, V37, P75, DOI 10.1002/(SICI)1521-3773(19980202)37:1/2<75::AID-ANIE75>3.0.CO
[3] 2-R
[4] Model systems for flavoenzyme activity. Regulation of flavin recognition via modulation of receptor hydrogen-bond donor-acceptor properties
Deans, R
Cooke, G
Rotello, VM
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (04) : 836 - 839
[5] IWAI I, 1968, CHEM ABS 69035M, V68
[6] ALLENES .43. A NOVEL SYNTHESIS OF PYRIMIDINES OF POTENTIAL PHARMACEUTICAL INTEREST FROM ALLENIC NITRILES
LANDOR, SR
LANDOR, PD
WILLIAMS, VE
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1984, (12): : 2677 - 2679
[7] LI JJ, 2000, PALLADIUM HETEROCYCL, V20
[8] Pozharskii A.F., 1997, HETEROCYCLES LIFE SO
[9] SMOLIN EM, 1959, S TRIAZINES DERIVATI, P217
[10] Catalytic cross-coupling reactions in biaryl synthesis
Stanforth, SP
[J]. TETRAHEDRON, 1998, 54 (3-4) : 263 - 303

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