Integrin-mediated signalling of gelatinase B secretion in colon cancer cells

被引：85

作者：

Niu, J ^{[1
]}

Gu, X

Turton, J

Meldrum, C

Howard, EW

Agrez, M

机构：

[1] Univ Newcastle, Fac Med & Hlth Sci, Discipline Surg Sci, Newcastle, NSW 2308, Australia

[2] John Hunter Hosp, Hunter Area Pathol Serv, New Lambton Hts, NSW 2305, Australia

[3] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 249卷 / 01期

关键词：

D O I：

10.1006/bbrc.1998.9128

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The progression of colon cancer has been linked to both cell adhesion molecules called integrins and matrix-degrading enzymes called metalloproteinases. Herein we report that the alpha v beta 6 integrin expressed in colon cancer cells induces gelatinase B secretion through the C-terminal cytoplasmic extension unique to the beta 6 integrin subunit, and that this ligand-independent event involves activation of the protein-kinase-C pathway. (C) 1998 Academic Press.

引用

页码：287 / 291

页数：5

共 17 条

[1] THE ALPHA-V-BETA-6 INTEGRIN PROMOTES PROLIFERATION OF COLON-CARCINOMA CELLS THROUGH A UNIQUE REGION OF THE BETA-6 CYTOPLASMIC DOMAIN [J].

AGREZ, M ;

CHEN, A ;

CONE, RI ;

PYTELA, R ;

SHEPPARD, D .

JOURNAL OF CELL BIOLOGY, 1994, 127 (02) :547-556

[2] Multiplicity of fibronectin-binding alpha(nu), integrin receptors in colorectal cancer [J].

Agrez, MV ;

Bates, RC ;

Mitchell, D ;

Wilson, N ;

Ferguson, N ;

Anseline, P ;

Sheppard, D .

BRITISH JOURNAL OF CANCER, 1996, 73 (07) :887-892

[3]

HOWARD EW, 1991, J BIOL CHEM, V266, P13064

[4]

HUHTALA P, 1991, J BIOL CHEM, V266, P16485

[5] INTEGRINS - VERSATILITY, MODULATION, AND SIGNALING IN CELL-ADHESION [J].

HYNES, RO .

CELL, 1992, 69 (01) :11-25

[6] ROLE AND REGULATION OF EXPRESSION OF 92-KDA TYPE-IV COLLAGENASE (MMP-9) IN 2 INVASIVE SQUAMOUS-CELL-CARCINOMA CELL-LINES OF THE ORAL CAVITY [J].

JUAREZ, J ;

CLAYMAN, G ;

NAKAJIMA, M ;

TANABE, KK ;

SAYA, H ;

NICOLSON, GL ;

BOYD, D .

INTERNATIONAL JOURNAL OF CANCER, 1993, 55 (01) :10-18

[7] Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans [J].

Kossakowska, AE ;

Huchcroft, SA ;

Urbanski, SJ ;

Edwards, DR .

BRITISH JOURNAL OF CANCER, 1996, 73 (11) :1401-1408

[8]

LAURICELLALEFEBVRE MA, 1993, INVAS METAST, V13, P289

[9]

MACKAY AR, 1992, INVAS METAST, V12, P168

[10]

SATO H, 1993, ONCOGENE, V8, P395

← 1 2 →