Aberrant methylation of HLTF, SOCS-1, and CDH13 genes is shown in colorectal cancers without lymph node metastasis

被引：20

作者：

Hibi, K ^{[1
]}

Kodera, Y ^{[1
]}

Ito, K ^{[1
]}

Akiyama, S ^{[1
]}

Nakao, A ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668560, Japan

来源：

DISEASES OF THE COLON & RECTUM | 2005年 / 48卷 / 06期

关键词：

methylation; colorectal cancer; HLTF; SOCS-1; CDH13;

D O I：

10.1007/s10350-004-0947-7

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

PURPOSE and METHODS: In this study, we examined the combined methylation status of HLTF, SOCS-1, and CDH13 in 61 resected primary colorectal cancers using methylation-specific polymerase chain reaction and correlated the number of methylated genes with the clinicopathologic features of affected patients. RESULTS: We found a significant difference in lymph node metastasis (P = 0.020) when we compared the number of methylated genes in colorectal cancers with lymph node metastasis to those without it. CONCLUSIONS: Colorectal cancers without lymph node metastasis frequently exhibited the aberrant methylation of HLTF, SOCS-1, and CDH13 genes.

引用

页码：1282 / 1286

页数：5

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