Comparison of adjuvants with respect to serum IgG antibody response in orally immunized chickens

被引：20

作者：

Hoshi, S ^{[1
]}

Uchino, A ^{[1
]}

Saito, N ^{[1
]}

Kusanagi, K ^{[1
]}

Ihara, T ^{[1
]}

Ueda, S ^{[1
]}

机构：

[1] Nippon Inst Biol Sci, Tokyo 1980024, Japan

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 1999年 / 22卷 / 01期

关键词：

saponin; NaF; mucosal adjuvant; chicken;

D O I：

10.1016/S0147-9571(98)00017-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have previously shown that oral immunization with non-replicating antigens hardly induced serum IgG antibody response in chickens and addition of sodium fluoride (NaF) to the immunogen markedly improved their immunological states. In the present study, taurine, lithium and Quillaja saponin (e-SAP) were compared with NaF with respect to their enhancement of serum IgG antibody response in chickens after oral immunization. The antibody titer of chickens which received e-SAP as the mucosal adjuvant tended to be higher than that of chickens which received antigen plus NaF. Simultaneous administration of antigen with lithium or taurine elicited a higher antibody titer in chickens compared to those of chickens orally immunized with antigen alone, but the effect of these two adjuvants was less efficient compared with that of NaF. These results suggested that e-SAP as well as NaF is useful as an oral adjuvant for chickens. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：63 / 69

页数：7

共 25 条

[1] In vitro activation of antigen-presenting cells (APC) by defined composition of Quillaja saponaria Molina triterpenoids [J].