Peroxyl radical scavenging activity of the antihypertensive drug carvedilol

被引：8

作者：

Aruoma, OI

机构：

[1] Pharmacology Group, University of London King's College, London SW3 6LX, Manresa Road

来源：

TOXICOLOGY IN VITRO | 1996年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0887-2333(96)00045-8

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The antihypertensive drug carvedilol was tested for its ability to scavenge peroxyl radicals by use of the model radical trichloromethyl peroxyl (CCl3O2). Carvedilol scavenged CCl3O2 with a calculated rate constant of 1.5 +/- 0.1 x 10(7)/M(-1) sec(-1). This ability to react rapidly with peroxyl radicals might be one mechanism by which carvedilol inhibits lipid peroxidation accounting for its reported antioxidant activity. Copyright (C) 1996 Elsevier Science Ltd.

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页码：625 / 629

页数：5

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