Mapping by admixture linkage disequilibrium: Advances, limitations and guidelines

被引：149

作者：

Smith, MW ^{[1
]}

O'Brien, SJ

机构：

[1] NCI, Lab Genom Divers, Frederick, MD 21702 USA

[2] NCI, Basic Re Program, SAIC Frederick, Frederick, MD 21702 USA

来源：

NATURE REVIEWS GENETICS | 2005年 / 6卷 / 08期

关键词：

D O I：

10.1038/nrg1657

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200-500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future.

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页码：623 / U6

页数：11

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